Additional Diabetes Information:
Diabetic Nephropathy is one of secondary nephropathies. There is no symptom in the early stage. Blood pressure is normal or a little high. The incidence increases along with the extension of the disease course. Diabetic Nephropathy is the main microvascular complication of Diabetic Syndrome. Diabetic Nephropathy chiefly refers to Glomerulosclerosis, a glomerular abnormality mainly with vascular impairment. Patients must go to a hospital if he finds the following symptoms:
The first triggering factor: Hypertension
It has no direct relationship with Diabetic Nephropathy. But the rising of original hypertension can speed up the deterioration of Diabetic Nephropathy, and the deterioration of kidney, and aggravate the ejection of Urinary Albumin.
The second factor: Hyperglycemia
The occurrence of Diabetic Nephropathy has a close relationship with Hyperglycemia. Poor blood glucose control will accelerate the occurrence and development of Diabetic Nephropathy. Good blood glucose control can obviously delay its development. The increasing of high blood sugar and glycosylation end product may cause hyperplasia of mesangial cells, extracellular matrix increase, mesangium expansion, and the thickening of Glomerular Basement Membrane, etc.
The third factor: Genetic Factor.
In most cases, Hypertensive Diabetes is the disease which belongs to old people. But most patients with Diabetes will not get nephropathy. Some patients whose blood sugar is under long-term control can also get Diabetic Nephropathy. Glucose transporter protein – 1(GLUT1)is the main glucose transporter on glomerular mesangial cells. So once there exist Glucose transporter protein – 1(GLUT1) in the body, the Diabetic Nephropathy will be genetic. adj
The fourth factor: Abnormal Renal Hemodynamics.
It plays a pivotal role during the occurrence of Diabetic Nephropathy. It even may be the startup factors.
(1) During the Hyperglycemia, the glomeruli are under the status of high perfusion and high filtration, and the pressure of cross capillary wall increases. which promotes the mesangial cells. The epithelial cell foot processes in the epithelial cells fuse produce dense droplets, and glomerular epithelial cells drop from the basilar membranes.
(2)Glomerular basement membrane collagen IV makes the sugar nucleic acid increase, and thickens the basilemma. Finally, nodular and diffuse lesion happen on the mesangium, and glomerulosclerosis takes place.
(3)Under the circumstance of increasing pressure, the protein filtration increases, and the protein deposits on the mesangium area and glomerular basement membrane, which in return promote matrix hyperplasia. The vicious circle takes place. What's worse, the deposition will also cause nodular and diffuse Glomerular Sclerosis.